Article
Mutation of MeCP2 alters transcriptional regulation of select immediate-early genes.
Epigenetics - 1 Feb 2012
Su Dan, Cha Young May, West Anne E
Abstract excerpt
Loss-of-function mutations in the methyl-DNA binding protein MeCP2 are associated with neurological dysfunction and impaired neural plasticity. However, the transcriptional changes that underlie these deficits remain poorly understood. Here, we show that mice bearing a C-terminal truncating mutation in Mecp2 (Mecp2 ( 308) ) are hypersensitive to the locomotor stimulating effects of cocaine. Furthermore, these...
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