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Article

Retinoblastoma protein regulates carcinogen susceptibility at heterochromatic cancer driver loci.

Life science alliance - 1 Apr 2022

Wong Ka Man, King Devin A, Schwartz Erin K, Herrera Rafael E, Morrison Ashby J

Abstract excerpt

Carcinogenic insult, such as UV light exposure, creates DNA lesions that evolve into mutations if left unrepaired. These resulting mutations can contribute to carcinogenesis and drive malignant phenotypes. Susceptibility to carcinogens (i.e., the propensity to form a carcinogen-induced DNA lesion) is regulated by both genetic and epigenetic factors. Importantly, carcinogen susceptibility is a critical contributor...

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Identifiers

PMID: 34983823
DOI: 10.26508/lsa.202101134
PMCID: PMC8739494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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