Article
A role for the Rb family of proteins in controlling telomere length.
Nature genetics - 1 Nov 2002
García-Cao Marta, Gonzalo Susana, Dean Douglas, Blasco María A
Abstract excerpt
The molecular mechanisms of cellular mortality have recently begun to be unraveled. In particular, it has been discovered that cells that lack telomerase are subject to telomere attrition with each round of replication, eventually leading to loss of telomere capping function at chromosome ends. Critically short telomeres and telomeres lacking telomere-binding proteins lose their functionality and are metabolized...
Topics
- Animals
- Cells, Cultured
- Chromosome Aberrations
- Chromosomes
- DNA
- Fibroblasts
- Flow Cytometry
- Genotype
- In Situ Hybridization, Fluorescence
- Mice
- Mice, Inbred C57BL
- Mice, Knockout