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Article

The helix 1-3 loop in the glucocorticoid receptor LBD is a regulatory element for FKBP cochaperones.

Molecular endocrinology (Baltimore, Md.) - 1 Jul 2013

Cluning Carmel, Ward Bryan K, Rea Sarah L, Arulpragasam Ajanthy, Fuller Peter J, Ratajczak Thomas

Abstract excerpt

The heat-shock protein 90 (Hsp90) cochaperone FK506-binding protein 52 (FKBP52) upregulates, whereas FKBP51 inhibits, hormone binding and nuclear targeting of the glucocorticoid receptor (GR). Decreased cortisol sensitivity in the guinea pig is attributed to changes within the helix 1 to helix 3 (H1-H3) loop of the guinea pig GR (gpGR) ligand-binding domain. It has been proposed that this loop serves as a contact...

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Identifiers

PMID: 23686112
DOI: 10.1210/me.2012-1023
PMCID: PMC5415241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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