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Article

Regulation of the glucocorticoid response to stress‐related disorders by the Hsp90‐binding immunophilin FKBP51

2 May 2012

Abstract excerpt

Immunophilin is the collective name given to a family of proteins that bind immunosuppressive drugs: Some immunophilins are Hsp90-binding cochaperones that affect steroid receptor function. Mood and anxiety disorders are stress-related diseases characterized by an impaired function of the mineralocorticoid and glucocorticoid receptors, two of the major regulatory elements of the...

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PMID: 22548329
DOI: 10.1111/j.1471-4159.2012.07775.x

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Regulation of the glucocorticoid response to stress‐related disorders by the Hsp90‐binding immunophilin FKBP51PMID 22548329Read ↗

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Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: Implications for major depressive disorderSemantic proximity Read ↗

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Differential Dynamics and Roles of FKBP51 Isoforms and Their Implications for Targeted TherapiesSemantic proximity Read ↗

FKBP51-Hsp90 Interaction-Deficient Mice Exhibit Altered Endocrine Stress Response and Sex Differences Under High-Fat DietSemantic proximity Read ↗

The rs1360780 Variant of FKBP5: Genetic Variation, Epigenetic Regulation, and Behavioral PhenotypesSemantic proximity Read ↗

Gene–environment interactions at the <i><scp>FKBP5</scp></i> locus: sensitive periods, mechanisms and pleiotropismSemantic proximity Read ↗

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