Article
Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90.
Acta crystallographica. Section D, Biological crystallography - 1 Jun 2011
Bracher Andreas, Kozany Christian, Thost Ann Katrin, Hausch Felix
Abstract excerpt
Steroid hormone receptors are key components of mammalian stress and sex hormone systems. Many of them rely on the Hsp90 chaperone system for full function and are further fine-tuned by Hsp90-associated peptidyl-prolyl isomerases such as FK506-binding proteins 51 and 52. FK506-binding protein 51 (FKBP51) has been shown to reduce glucocorticoid receptor signalling and has been genetically associated with human...
Topics
- Amino Acid Sequence
- Animals
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Peptidylprolyl Isomerase
- Protein Structure, Tertiary
- Sequence Alignment
- Sequence Homology, Amino Acid