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Article

Specificity control for read alignments using an artificial reference genome-guided false discovery rate.

Bioinformatics (Oxford, England) - 1 Jan 2014

Giese Sven H, Zickmann Franziska, Renard Bernhard Y

Abstract excerpt

MOTIVATION: Accurate estimation, comparison and evaluation of read mapping error rates is a crucial step in the processing of next-generation sequencing data, as further analysis steps and interpretation assume the correctness of the mapping results. Current approaches are either focused on sensitivity estimation and thereby disregard specificity or are based on read simulations. Although continuously improving,...

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PMID: 23685787
DOI: 10.1093/bioinformatics/btt255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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