Article
An investigation of causes of false positive single nucleotide polymorphisms using simulated reads from a small eukaryote genome.
BMC bioinformatics - 11 Nov 2015
Ribeiro Antonio, Golicz Agnieszka, Hackett Christine Anne, Milne Iain, Stephen Gordon, Marshall David, Flavell Andrew J, Bayer Micha
Abstract excerpt
BACKGROUND: Single Nucleotide Polymorphisms (SNPs) are widely used molecular markers, and their use has increased massively since the inception of Next Generation Sequencing (NGS) technologies, which allow detection of large numbers of SNPs at low cost. However, both NGS data and their analysis are error-prone, which can lead to the generation of false positive (FP) SNPs. We explored the relationship between FP...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.