Article
Improving read alignment through the generation of alternative reference via iterative strategy.
Scientific reports - 30 Oct 2020
Bu Lina, Wang Qi, Gu Wenjin, Yang Ruifei, Zhu Di, Song Zhuo, Liu Xiaojun, Zhao Yiqiang
Abstract excerpt
There is generally one standard reference sequence for each species. When extensive variations exist in other breeds of the species, it can lead to ambiguous alignment and inaccurate variant calling and, in turn, compromise the accuracy of downstream analysis. Here, with the help of the FPGA hardware platform, we present a method that generates an alternative reference via an iterative strategy to improve the...
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