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Article

Accurate estimation of short read mapping quality for next-generation genome sequencing.

Bioinformatics (Oxford, England) - 15 Sept 2012

Ruffalo Matthew, Koyutürk Mehmet, Ray Soumya, LaFramboise Thomas

Abstract excerpt

MOTIVATION: Several software tools specialize in the alignment of short next-generation sequencing reads to a reference sequence. Some of these tools report a mapping quality score for each alignment-in principle, this quality score tells researchers the likelihood that the alignment is correct. However, the reported mapping quality often correlates weakly with actual accuracy and the qualities of many mappings...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22962451
DOI: 10.1093/bioinformatics/bts408
PMCID: PMC3436835

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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