Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes.

Biochimica et biophysica acta - 1 Oct 2013

Aguer Céline, Pasqua Melissa, Thrush A Brianne, Moffat Cynthia, McBurney Michael, Jardine Karen, Zhang Rui, Beauchamp Brittany, Dent Robert, McPherson Ruth, Harper Mary-Ellen

Abstract excerpt

Muscle insulin resistance is linked to oxidative stress and decreased mitochondrial function. However, the exact cause of muscle insulin resistance is still unknown. Since offspring of patients with type 2 diabetes mellitus (T2DM) are susceptible to developing insulin resistance, they are ideal for studying the early development of insulin resistance. By using primary muscle cells derived from obese non-diabetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to DNA, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin Resistance

Share to Membrane Potential, Mitochondrial

Share to Muscle Fibers, Skeletal

Share to Obesity

Share to Protons

Share to Superoxide Dismutase

Source

Identifiers

PMID: 23685312
DOI: 10.1016/j.bbadis.2013.05.008

Genes

SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased proton leak and SOD2 expression in myotubes from obese non-diabetic subjects with a family history of type 2 diabetes.PMID 23685312Read ↗

Impaired Mitochondrial Activity and Insulin-Resistant Offspring of Patients with Type 2 DiabetesSemantic proximity Read ↗

Is Type 2 Diabetes a Primary Mitochondrial Disorder?Semantic proximity Read ↗

Diabetes in a Dish: Modeling and Phenotyping Acute and Chronic Type 2 Diabetes Mellitus In Vitro in Rodent Heart and Skeletal Muscle CellsSemantic proximity Read ↗

Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?Semantic proximity Read ↗

A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance.Semantic proximity Read ↗

Increased mitochondrial respiration of adipocytes from metabolically unhealthy obese compared to healthy obese individuals.Semantic proximity Read ↗

Mitochondria and diabetes mellitus: untangling a conflictive relationship?Semantic proximity Read ↗

Excessive iron accumulation mediated oxidative stress and β-cell dysfunction via perturbations of insulin secretion in MIN6 cellsSemantic proximity Read ↗

Subjects With Early-Onset Type 2 Diabetes Show Defective Activation of the Skeletal Muscle PGC-1α/Mitofusin-2 Regulatory Pathway in Response to Physical ActivitySemantic proximity Read ↗

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.Semantic proximity Read ↗

Insulin prevents aberrant mitochondrial phenotype in sensory neurons of type 1 diabetic rats.Semantic proximity Read ↗

A primary reduced TCA flux governs substrate oxidation in T2D skeletal muscle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.