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Article

Does skeletal muscle oxidative stress initiate insulin resistance in genetically predisposed individuals?

Trends in endocrinology and metabolism: TEM - 1 Feb 2010

Samocha-Bonet Dorit, Heilbronn Leonie K, Lichtenberg Dov, Campbell Lesley V

Abstract excerpt

Reactive oxygen species (ROS) are postulated to be a common trigger of insulin resistance. For example, treatment of adipocytes with either tumor-necrosis factor-alpha or dexamethasone increases ROS before impairing glucose uptake. Similarly, treatment with mitochondria-specific antioxidants pres...

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Source

Identifiers

PMID: 19854062
DOI: 10.1016/j.tem.2009.09.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19854062-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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