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Article

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents.

PLoS medicine - 1 Sept 2005

Petersen Kitt F, Dufour Sylvie, Shulman Gerald I

Abstract excerpt

BACKGROUND: Insulin resistance is the best predictor for the development of type 2 diabetes. Recent studies have shown that young, lean, insulin-resistant (IR) offspring of parents with type 2 diabetes have reduced basal rates of muscle mitochondrial phosphorylation activity associated with incre...

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Topics

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Share to Calorimetry, Indirect
Share to Glucose Clamp Technique
Share to Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Metabolism

Share to Magnetic Resonance Spectroscopy

Share to Mitochondria, Muscle

Share to Oxidative Phosphorylation

Share to Phosphates

Source

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Identifiers

PMID: 16089501
DOI: 10.1371/journal.pmed.0020233
PMCID: PMC1184227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16089501-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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