Article

TRAP1 controls the crosstalk between SDHA/HIF-1α, HIF/ERK1/2/Twist, and HIF/FoxC/Twist pathways via HIF-1α during EMT in colorectal cancer

2023-08-14

Abstract excerpt

<title>Abstract</title> Background Tumor necrosis factor receptor-associated protein 1 (TRAP1) is highly-expressed during epithelial-mesenchymal transition (EMT) in colorectal cancer (CRC). Here, we investigated the mechanism underlying the high expression of TRAP1 during EMT and evaluated the potential of TRAP1 as a therapeutic target for metastatic CRC treatment. Moreover, we discussed ways to improve the...

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Literature Corpus work: 64de16a7-ae8b-5dc1-90a8-b67cf65c87d8
DOI: 10.21203/rs.3.rs-3148879/v1

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