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Article

Aberrant expression of hypoxia-inducible factor 1α, TWIST and E-cadherin is associated with aggressive tumor phenotypes in endometrioid endometrial carcinoma.

Japanese journal of clinical oncology - 1 Apr 2013

Feng Zhenzhong, Gan Huaiyong, Cai Zhaogen, Li Nan, Yang Zhaorui, Lu Guangzhong, Chen Jiawei

Abstract excerpt

OBJECTIVE: Intratumoral hypoxia promotes angiogenesis, invasion and epithelial-mesenchymal transition, a pivotal event in tumor metastasis. TWIST is a master regulator of multiple developmental processes and has recently been shown to be the key factor responsible for cancer metastasis via the inhibition of E-cadherin expression, a hallmark of epithelial-mesenchymal transition. This study aimed to determine the...

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Source

Identifiers

PMID: 23372184
DOI: 10.1093/jjco/hys237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Aberrant expression of hypoxia-inducible factor 1α, TWIST and E-cadherin is associated with aggressive tumor phenotypes in endometrioid endometrial carcinoma.PMID 23372184Read ↗

Direct regulation of TWIST by HIF-1alpha promotes metastasis.Semantic proximity Read ↗

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TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and developmentSemantic proximity Read ↗

Over-Expressed Twist Associates with Markers of Epithelial Mesenchymal Transition and Predicts Poor Prognosis in Breast Cancers via ERK and Akt ActivationSemantic proximity Read ↗

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other DiseasesSemantic proximity Read ↗

Twist mediates an aggressive phenotype in human colorectal cancer cells.Semantic proximity Read ↗

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Role of Epithelial-to-Mesenchymal Transition Markers in Different Stages of Endometriosis: Expression of the Snail, Slug, ZEB1, and Twist GenesSemantic proximity Read ↗

High-Risk Endometrial Carcinoma Profiling Identifies TGF-β1 as a Key Factor in the Initiation of Tumor InvasionSemantic proximity Read ↗

Involvement of the transcription factor twist in phenotype alteration through epithelial–mesenchymal transition in lung cancer cellsSemantic proximity Read ↗

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