Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

L1-Mediated Colon Cancer Cell Metastasis Does Not Require Changes in EMT and Cancer Stem Cell Markers

2 Dec 2010

Abstract excerpt

Aberrant activation of Wnt/β-catenin signaling is common in most sporadic and inherited colorectal cancer (CRC) cells leading to elevated β-catenin/TCF transactivation. We previously identified the neural cell adhesion molecule L1 as a target gene of β-catenin/TCF in CRC cells. Forced expression of L1 confers increased cell motility, invasion, and tumorigenesis, and the induction of human CRC cell metastasis to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axon Guidance and Neuronal Signaling
Share to Cancer Cells and Metastasis
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21123622
DOI: 10.1158/1541-7786.mcr-10-0406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

L1-Mediated Colon Cancer Cell Metastasis Does Not Require Changes in EMT and Cancer Stem Cell MarkersPMID 21123622Read ↗

Wnt/β-Catenin Target Genes in Colon Cancer Metastasis: The Special Case of L1CAMSemantic proximity Read ↗

Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasisSemantic proximity Read ↗

Nuclear factor-κB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cellsSemantic proximity Read ↗

L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancersSemantic proximity Read ↗

SNAIL1 employs β‐Catenin‐LEF1 complexes to control colorectal cancer cell invasion and proliferationSemantic proximity Read ↗

L1 cell adhesion molecule (L1CAM) in invasive tumors.Semantic proximity Read ↗

L1 augments cell migration and tumor growth but not β3 integrin expression in ovarian carcinomasSemantic proximity Read ↗

Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell linesSemantic proximity Read ↗

L1 cell adhesion molecules as regulators of tumor cell invasivenessSemantic proximity Read ↗

The role of Snail1 transcription factor in colorectal cancer progression and metastasisSemantic proximity Read ↗

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors.Semantic proximity Read ↗

Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival of multiple human colorectal cancer cell linesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.