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Article

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.

Thrombosis research - 1 Jul 2009

Zhou Zhou, Jing Hua, Tao Zhenyin, Choi Huiwan, Aboulfatova Khatira, Moake Joel, Li Renhao, Dong Jing-Fei

Abstract excerpt

INTRODUCTION: Upon stimulation, endothelial cells release von Willebrand factor (VWF) in the unusually large (UL) and hyperactive forms that are rapidly cleaved by ADAMTS-13. Mutations in the ADAMTS13 gene result in ULVWF-mediated thrombosis found in patients with familial thrombotic thrombocytopenia purpura (TTP). ADAMTS-13 fits in the consensus of the ADAMTS family metalloproteases, but also contains two unique...

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Source

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Identifiers

PMID: 19027144
DOI: 10.1016/j.thromres.2008.09.007
PMCID: PMC5649364

Genes

VWF
ADAMTS13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.PMID 19027144Read ↗

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