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Article

Alternative splicing of the metalloprotease ADAMTS17 spacer regulates secretion and modulates autoproteolytic activity.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2021

Balic Zerina, Misra Saurav, Willard Belinda, Reinhardt Dieter P, Apte Suneel S, Hubmacher Dirk

Abstract excerpt

ADAMTS proteases mediate biosynthesis and breakdown of secreted extracellular matrix (ECM) molecules in numerous physiological and disease processes. In addition to their catalytic domains, ADAMTS proteases contain ancillary domains, which mediate substrate recognition and ECM binding and confer distinctive properties and roles to individual ADAMTS proteases. Although alternative splicing can greatly expand the...

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PMID: 33484187
DOI: 10.1096/fj.202001120RR
PMCID: PMC8133003

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