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Article

Essential role of the disintegrin-like domain in ADAMTS13 function.

Blood - 28 May 2009

de Groot Rens, Bardhan Ajoy, Ramroop Nalisha, Lane David A, Crawley James T B

Abstract excerpt

ADAMTS13 is a highly specific multidomain plasma metalloprotease that regulates the multimeric size and function of von Willebrand factor (VWF) through cleavage at a single site in the VWF A2 domain. The precise role that the ADAMTS13 disintegrin-like domain plays in its function remains uncertain. Truncated ADAMTS13 variants suggested the importance of the disintegrin-like domain for both enzyme activity and...

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Source

Identifiers

PMID: 19234142
DOI: 10.1182/blood-2008-11-187914

Genes

ADAMTS13
VWF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Essential role of the disintegrin-like domain in ADAMTS13 function.PMID 19234142Read ↗

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