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Article

Identification of a crucial tryptophan residue in ADAMTS13 required for its secretion and enzymatic activity.

Clinical and experimental pharmacology & physiology - 1 Nov 2018

Ling Jing, Ma Zhenni, Liu Ling, Yin Jie, Su Jian, Shen Fei, Xie Liqian, Hu Shaoyan

Abstract excerpt

Functional deficiency of A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)13 causally assists in the pathology of thrombotic thrombocytopenic purpura (TTP). Previous study showed that the WXXW motif is very important to the enzymatic activity of ADAMTS13. However, the functional role for a single amino acid residue within WXXW motif is still undetermined. Here, Trp390 residue within WXXW...

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Source

Identifiers

PMID: 29920743
DOI: 10.1111/1440-1681.12996

Genes

ADAMTS13
VWF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Identification of a crucial tryptophan residue in ADAMTS13 required for its secretion and enzymatic activity.PMID 29920743Read ↗

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