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Article

Analysis of the role of vaccinia virus H7 in virion membrane biogenesis with an H7-deletion mutant.

Journal of virology - 1 Jul 2013

Meng Xiangzhi, Wu Xiang, Yan Bo, Deng Junpeng, Xiang Yan

Abstract excerpt

Essential vaccinia virus genes are often studied with conditional-lethal inducible mutants. Here, we constructed a deletion mutant lacking the essential H7R gene (the ΔH7 mutant) with an H7-expressing cell line. Compared to an inducible H7 mutant, the ΔH7 mutant showed a defect at an earlier step of virion membrane biogenesis, before the development of short crescent-shaped precursors of the viral envelope. Our...

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Identifiers

PMID: 23678177
DOI: 10.1128/JVI.00845-13
PMCID: PMC3700178

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Source receipt: pubmed, retrieved 7 Sept 2026.

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