Article
Vaccinia virus E2L null mutants exhibit a major reduction in extracellular virion formation and virus spread.
Journal of virology - 1 May 2008
Domi Arban, Weisberg Andrea S, Moss Bernard
Abstract excerpt
The vaccinia virus E2L (VACWR058) gene is conserved in all sequenced chordopoxviruses and is predicted to encode an 86-kDa protein with no recognizable functional motifs or nonpoxvirus homologs. Although the region immediately upstream of the open reading frame lacked optimal consensus promoter motifs, expression of the E2 protein occurred after viral DNA replication. Transfection studies, however, indicated that...
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