Article
Non-ahr gene susceptibility Loci for porphyria and liver injury induced by the interaction of 'dioxin' with iron overload in mice.
Molecular pharmacology - 1 Mar 2002
Robinson Susan W, Clothier Bruce, Akhtar Ruth A, Yang Ai Li, Latour Isabelle, Van Ijperen Carola, Festing Michael F W, Smith Andrew G
Abstract excerpt
Among the actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in mice is the induction of hepatic porphyria. This is similar to the most common disease of this type in humans, sporadic porphyria cutanea tarda (PCT). Evidence is consistent with the actions of dioxin being mediated through binding to the aryl hydrocarbon receptor (AHR) with different Ahr alleles in mouse strains apparently accounting for...
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