Glycine 119 of bovine growth hormone is critical for growth-promoting activity.

doi:10.1210/mend-5-12-1845

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Article

Glycine 119 of bovine growth hormone is critical for growth-promoting activity.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 1991

Chen W Y, Wight D C, Mehta B V, Wagner T E, Kopchick J J

Abstract excerpt

Bovine GH (bGH) analogs with single amino acid substitutions at positions 117 (bGH-E117L), 119 (bGH-G119R), and 122 (bGH-A122D) were generated. These analogs bind to mouse liver membrane preparations with affinities similar to native bGH. However, transgenic mice which express the analogs demonst...

Topics

Alanine
Amino Acid Sequence
Animals
Base Sequence
Cell Membrane
Cells, Cultured
DNA
Dwarfism
Electrophoresis, Polyacrylamide Gel
Female
Gene Expression
Glycine
Growth
Growth Hormone
Immunoblotting
Liver
Male
Mice

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