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Glycine 119 of bovine growth hormone is critical for growth-promoting activity.

Molecular endocrinology (Baltimore, Md.) - 1 Dec 1991

Chen W Y, Wight D C, Mehta B V, Wagner T E, Kopchick J J

Abstract excerpt

Bovine GH (bGH) analogs with single amino acid substitutions at positions 117 (bGH-E117L), 119 (bGH-G119R), and 122 (bGH-A122D) were generated. These analogs bind to mouse liver membrane preparations with affinities similar to native bGH. However, transgenic mice which express the analogs demonstrate different phenotypes ranging from dwarfism to gigantism. For example, expression of bGH or bGH-E117L result in...

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PMID: 1791834
DOI: 10.1210/mend-5-12-1845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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