Article
Extensive phenotypic characterization of a new transgenic mouse reveals pleiotropic perturbations in physiology due to mesenchymal hGH minigene expression.
Scientific reports - 25 May 2017
Kaklamanos Aimilios, Rozman Jan, Roulis Manolis, Karagianni Niki, Armaka Maria, Wu Moya, Brachthäuser Laura, Calzada-Wack Julia, Horsch Marion, Beckers Johannes, Rathkolb Birgit, Adler Thure, Neff Frauke, Wolf Eckhard, Gailus-Durner Valerie, Fuchs Helmut, de Angelis Martin Hrabe, Kollias George
Abstract excerpt
The human growth hormone (hGH) minigene used for transgene stabilization in mice has been recently identified to be locally expressed in the tissues where transgenes are active and associated with phenotypic alterations. Here we extend these findings by analyzing the effect of the hGH minigene in TgC6hp55 transgenic mice which express the human TNFR1 under the control of the mesenchymal cell-specific CollagenVI...
Topics
- Animals
- Collagen Type VI
- Female
- Gene Expression
- Gene Expression Regulation
- Glucose
- Human Growth Hormone
- Humans
- Male