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Article

A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation.

The Journal of biological chemistry - 28 Jun 2013

Friis Stine, Uzzun Sales Katiuchia, Godiksen Sine, Peters Diane E, Lin Chen-Yong, Vogel Lotte K, Bugge Thomas H

Abstract excerpt

Matriptase and prostasin are part of a cell surface proteolytic pathway critical for epithelial development and homeostasis. Here we have used a reconstituted cell-based system and transgenic mice to investigate the mechanistic interrelationship between the two proteases. We show that matriptase and prostasin form a reciprocal zymogen activation complex with unique features. Prostasin serves as a critical...

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Identifiers

PMID: 23673661
DOI: 10.1074/jbc.M113.469932
PMCID: PMC3696676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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