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Article

Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation.

The Journal of biological chemistry - 3 Nov 2006

Netzel-Arnett Sarah, Currie Brooke M, Szabo Roman, Lin Chen-Yong, Chen Li-Mei, Chai Karl X, Antalis Toni M, Bugge Thomas H, List Karin

Abstract excerpt

Recent gene ablation studies in mice have shown that matriptase, a type II transmembrane serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine protease, are both required for processing of the epidermis-specific polyprotein, profilaggrin, stratum corneum formation, and acquisition of epidermal barrier function. Here we present evidence that matriptase acts upstream of prostasin...

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PMID: 16980306
DOI: 10.1074/jbc.C600208200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation.PMID 16980306Read ↗

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