Article
Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
The Journal of biological chemistry - 12 Apr 2013
Raman Kavita, Trivedi Neil N, Raymond Wilfred W, Ganesan Rajkumar, Kirchhofer Daniel, Verghese George M, Craik Charles S, Schneider Eric L, Nimishakavi Shilpa, Caughey George H
Abstract excerpt
Human and mouse marapsins (Prss27) are serine proteases preferentially expressed by stratified squamous epithelia. However, mouse marapsin contains a transmembrane anchor absent from the human enzyme. To gain insights into physical forms, activities, inhibition, and roles in epithelial differentiation, we traced tail loss in human marapsin to a nonsense mutation in an ancestral ape, compared substrate preferences...
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