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Article

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

1 Aug 2000

Abstract excerpt

Matrix metalloproteinases (MMPs) are synthesized as latent proenzymes. A proteolytic cleavage event involving processing of the cysteine-rich N-terminal propeptide is required for their full activation. Previous in vitro studies indicated that activation of proMMP-2 can occur through formation of a trimolecular complex between MMP-14, TIMP-2, and proMMP-2 at the cell surface. Using TIMP-2-deficient mice and cells...

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PMID: 10827175
DOI: 10.1074/jbc.m001270200

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