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Article

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.

The Journal of clinical investigation - 1 Sept 2008

Chiang Mark Y, Xu Lanwei, Shestova Olga, Histen Gavin, L'heureux Sarah, Romany Candice, Childs M Eden, Gimotty Phyllis A, Aster Jon C, Pear Warren S

Abstract excerpt

Gain-of-function NOTCH1 mutations are found in 50%-70% of human T cell acute lymphoblastic leukemia/lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in mice, but it is unknown whether the gain-of-function NOTCH1 mutations most commonl...

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Share to Cell Line, Tumor
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Mice, Inbred C57BL

Share to Models, Biological

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Receptor, Notch1

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Source

Open in PubMed Open full text

Identifiers

PMID: 18677410
DOI: 10.1172/JCI35090
PMCID: PMC2491459

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18677410-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia.PMID 18677410Read ↗

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