Article
Crystal structure and functional insights into uracil-DNA glycosylase inhibition by phage Φ29 DNA mimic protein p56.
Nucleic acids research - 1 Jul 2013
Baños-Sanz José Ignacio, Mojardín Laura, Sanz-Aparicio Julia, Lázaro José M, Villar Laurentino, Serrano-Heras Gemma, González Beatriz, Salas Margarita
Abstract excerpt
Uracil-DNA glycosylase (UDG) is a key repair enzyme responsible for removing uracil residues from DNA. Interestingly, UDG is the only enzyme known to be inhibited by two different DNA mimic proteins: p56 encoded by the Bacillus subtilis phage 29 and the well-characterized protein Ugi encoded by the B. subtilis phage PBS1/PBS2. Atomic-resolution crystal structures of the B. subtilis UDG both free and in complex...
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