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Article

Novel dimeric structure of phage φ29-encoded protein p56: insights into uracil-DNA glycosylase inhibition.

Nucleic acids research - 1 Dec 2011

Asensio Juan Luis, Pérez-Lago Laura, Lázaro José M, González Carlos, Serrano-Heras Gemma, Salas Margarita

Abstract excerpt

Protein p56 encoded by the Bacillus subtilis phage φ29 inhibits the host uracil-DNA glycosylase (UDG) activity. To get insights into the structural basis for this inhibition, the NMR solution structure of p56 has been determined. The inhibitor defines a novel dimeric fold, stabilized by a combination of polar and extensive hydrophobic interactions. Each polypeptide chain contains three stretches of anti-parallel...

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Identifiers

PMID: 21890898
DOI: 10.1093/nar/gkr667
PMCID: PMC3239192

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