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Article

Selective interactions between mimivirus uracil-DNA glycosylase and inhibitory proteins determined by a single amino acid.

Journal of structural biology - 1 Sept 2020

Pathak Deepak, Kwon Eunju, Kim Dong Young

Abstract excerpt

Uracil-N-glycosylase (UNG) is found in most organisms as well as in large DNA viruses. Its inhibitory proteins, including uracil glycosylase inhibitor (UGI) and p56, tightly bind to the active site of UNG by mimicking the DNA substrates. As the binding motifs are conserved in UNG family proteins, the inhibitory proteins bind to various UNG proteins across species. However, the intercalation residue that...

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Identifiers

PMID: 32569642
DOI: 10.1016/j.jsb.2020.107552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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