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Article

Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase.

Nucleic acids research - 1 Oct 2013

Cole Ambrose R, Ofer Sapir, Ryzhenkova Ksenia, Baltulionis Gediminas, Hornyak Peter, Savva Renos

Abstract excerpt

Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis. Viral proteins targeting UDG, such as the bacteriophage proteins ugi, and p56, and the HIV-1 protein Vpr, share no sequence similarity, and are not structurally homologous. Such diversity has hindered...

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Identifiers

PMID: 23892286
DOI: 10.1093/nar/gkt633
PMCID: PMC3794593

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