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Article

Search for mutations in signaling pathways in head and neck squamous cell carcinoma.

Oncology reports - 1 Jul 2013

De Carvalho Thais Gulim, De Carvalho Ana Carolina, Maia Danielle Calheiros Campelo, Ogawa Juliana Kaori, Carvalho Andre Lopes, Vettore Andre Luiz

Abstract excerpt

Mutations in JAK-STAT signaling pathway genes have been associated with the development of various hematological tumors, but have not been investigated in head and neck tumors, and the PIK3CA, BRAF and KRAS genes have been described in a few cases of head and neck squamous cell carcinoma (HNSCC). In the present study, we determined the mutation status in members of the MAPK, PI3K-AKT and JAK-STAT pathways in...

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Identifiers

PMID: 23670291
DOI: 10.3892/or.2013.2455

Genes

BRAF
KRAS
JAK1
JAK2

Provenance

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