Article
Engineered monoclonal antibody with novel antigen-sweeping activity in vivo.
PloS one - 1 Jan 2013
Igawa Tomoyuki, Maeda Atsuhiko, Haraya Kenta, Tachibana Tatsuhiko, Iwayanagi Yuki, Mimoto Futa, Higuchi Yoshinobu, Ishii Shinya, Tamba Shigero, Hironiwa Naoka, Nagano Kozue, Wakabayashi Tetsuya, Tsunoda Hiroyuki, Hattori Kunihiro
Abstract excerpt
Monoclonal antibodies are widely used to target disease-related antigens. However, because conventional antibody binds to the antigen but cannot eliminate the antigen from plasma, and rather increases the plasma antigen concentration by reducing the clearance of the antigen, some clinically important antigens are still difficult to target with monoclonal antibodies because of the huge dosages required. While...
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