Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Manipulating T cell-mediated pathology: Targets and functions of monoclonal antibody immunotherapy

28 Apr 2013

Abstract excerpt

Monoclonal antibody (mAb) technology has revolutionized treatment options for T cell mediated diseases. However, a safe, clinically available anti-T cell antibody (ab) remains elusive. Experience with anti-T cell agents and their propensity for causing immune-mediated toxicities have hampered the development of anti-T cell mAb's. Furthermore, misunderstanding regarding mechanism(s) of action of particular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CAR-T cell therapy research
Share to Immune Cell Function and Interaction
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23688653
DOI: 10.1016/j.clim.2013.04.011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Manipulating T cell-mediated pathology: Targets and functions of monoclonal antibody immunotherapyPMID 23688653Read ↗

Monoclonal antibodies: From magic bullet to precision weaponSemantic proximity Read ↗

Antibody therapeutics:Semantic proximity Read ↗

Biological impediments to monoclonal antibody–based cancer immunotherapySemantic proximity Read ↗

CAR-T AND autoimmune diseases in nervous systemSemantic proximity Read ↗

New insights into T cell biology and T cell‐directed therapy for autoimmunity, inflammation, and immunosuppressionSemantic proximity Read ↗

Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in ImmunotherapySemantic proximity Read ↗

Immunogenicity of Monoclonal Antibodies and the Potential Use of HLA Haplotypes to Predict Vulnerable PatientsSemantic proximity Read ↗

Targeting plasma cells: are we any closer to a panacea for diseases of antibody-secreting cells?Semantic proximity Read ↗

Selective Immune Silencing by Targeted TGF-β AgonistsSemantic proximity Read ↗

Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignanciesSemantic proximity Read ↗

Molecular engineering to improve antibodies' anti-lymphoma activity.Semantic proximity Read ↗

Therapy with monoclonal antibodies. II. The contribution of Fc gamma receptor binding and the influence of C(H)1 and C(H)3 domains on in vivo effector function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.