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Article

Covariates of tramadol disposition in the first months of life.

British journal of anaesthesia - 1 Apr 2008

Allegaert K, van den Anker J N, de Hoon J N, van Schaik R H N, Debeer A, Tibboel D, Naulaers G, Anderson B J

Abstract excerpt

BACKGROUND: Data on contributors to between-individual variability in overall tramadol clearance and O-demethyl tramadol (M1) formation in preterm neonates and young infants are limited. METHODS: A population pharmacokinetic analysis of tramadol and M1 was undertaken using non-linear mixed effects model. Covariate analysis included weight, postmenstrual age (PMA), postnatal age (PNA), creatinaemia, (cardiac)...

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Source

Identifiers

PMID: 18303070
DOI: 10.1093/bja/aen019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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