Article
Population pharmacokinetics of rectal theophylline in neonates.
Therapeutic drug monitoring - 1 May 1991
Karlsson M O, Thomson A H, McGovern E M, Chow P, Evans T J, Kelman A W
Abstract excerpt
The population pharmacokinetics of theophylline were studied in 35 neonates receiving aminophylline suppositories for the treatment of apnoea of prematurity. Routinely measured theophylline serum concentrations (n = 138, range 3-20 mg/L) were modelled in NONMEM according to a one-compartment model. The influence of a number of clinical and demographic factors, e.g., weight (range 0.8-2.5 kg) and postnatal age...
Topics
- Administration, Rectal
- Dose-Response Relationship, Drug
- Female
- Genetic Variation
- Humans
- Infant, Newborn
- Male
- Models, Biological
- Regression Analysis
- Theophylline