Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly

25 Dec 2024

Abstract excerpt

The pharmacokinetics (PK) of piperacillin/tazobactam (PIP/TAZ) is highly variable across different patient populations and there are controversies regarding non-linear elimination as well as the fraction unbound of PIP ( f UNB_PIP ). This has led to a plethora of subgroup-specific models, increasing the risk of misusing published models when optimising dosing regimens. In this study, we aimed to develop a single...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics Pharmacokinetics and Efficacy
Share to Blood disorders and treatments
Share to Neonatal and Maternal Infections

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39722108
DOI: 10.1007/s40262-024-01460-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the ElderlyPMID 39722108Read ↗

Comparison of Pooled and Bayesian population PK approaches in pediatric PK analysis leveraging prior adult knowledge: A case study exploring considerations for mAbsSemantic proximity Read ↗

Maternal Betamethasone for Prevention of Respiratory Distress Syndrome in Neonates: Population Pharmacokinetic and Pharmacodynamic Approach.Semantic proximity Read ↗

Influence of NAT2 Genotype and Maturation on Isoniazid Exposure in Low-Birth-Weight and Preterm Infants With or Without Human Immunodeficiency Virus (HIV) Exposure.Semantic proximity Read ↗

Model-Informed Precision Dosing of Isoniazid: Parametric Population Pharmacokinetics Model Repository.Semantic proximity Read ↗

Application of stochastic simulation-estimation approach to the optimization of Pharmacokinetic studies design in the context of paediatric extrapolation: A step toward better decision making for drug sponsors and regulatorsSemantic proximity Read ↗

Modelling, Extrapolation and Simulation approaches for rare diseases - Review of two case-studies in the INVENTS projectSemantic proximity Read ↗

Physiologically Based Pharmacokinetic Modeling to Determine the Impact of CYP2B6 Genotype on Efavirenz Exposure in Children, Mothers and Breastfeeding Infants.Semantic proximity Read ↗

Vancomycin Population Pharmacokinetic Models in Non- Critically Ill Adults Patients: a scoping reviewSemantic proximity Read ↗

Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma.Semantic proximity Read ↗

Pediatric Clinical Pharmacology of Voriconazole: Role of Pharmacokinetic/Pharmacodynamic Modeling in Pharmacotherapy.Semantic proximity Read ↗

Population pharmacokinetic modeling and Monte Carlo simulation-based dosing optimization of trimethoprim-sulfamethoxazole in critically ill patients.Semantic proximity Read ↗

Estrogen profile- and pharmacogenetics-based lamotrigine dosing regimen optimization: Recommendations for pregnant women with epilepsy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.