Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes.

Drugs in R&D - 1 Jun 2024

Chen Zhendong, Taubert Max, Chen Chunli, Boland Jana, Dong Qian, Bilal Muhammad, Dokos Charalambos, Wachall Bertil, Wargenau Manfred, Scheidel Bernhard, Wiesen Martin H J, Schaeffeler Elke, Tremmel Roman, Schwab Matthias, Fuhr Uwe

Abstract excerpt

INTRODUCTION: Noscapine is a commonly used cough suppressant, with ongoing research on its anti-inflammatory and anti-tumor properties. The drug has a pronounced pharmacokinetic variability. OBJECTIVE: This evaluation aims to describe the pharmacokinetics of noscapine using a semi-mechanistic population pharmacokinetic model and to identify covariates that could explain inter-individual pharmacokinetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Administration, Oral
Share to Cross-Over Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Genotype

Share to Healthy Volunteers

Share to Models, Biological

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 38809387
DOI: 10.1007/s40268-024-00466-6
PMCID: PMC11315837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Semi-Mechanistic Population Pharmacokinetic Model of Noscapine in Healthy Subjects Considering Hepatic First-Pass Extraction and CYP2C9 Genotypes.PMID 38809387Read ↗

Development of a predictive pharmacokinetic model for a novel cyclooxygenase-2 inhibitor.Semantic proximity Read ↗

Escitalopram population pharmacokinetics and remedial strategies based on CYP2C19 phenotype.Semantic proximity Read ↗

Clinical pharmacokinetic registration file for NDA and ANDA procedures.Semantic proximity Read ↗

Physiologically based pharmacokinetic (PBPK) modeling of meloxicam in different CYP2C9 genotypes.Semantic proximity Read ↗

Exploring the Population Pharmacokinetic and Pharmacogenetics Characteristics of Flurbiprofen Isomers in Selective Joint Replacement Patients with Postoperative Pain.Semantic proximity Read ↗

Estimation of CYP2D6*10 genotypes on citalopram disposition in Chinese subjects by population pharmacokinetic assay.Semantic proximity Read ↗

Biopharmaceutical Classification System (BCS)Semantic proximity Read ↗

PBPK Modeling of Esomeprazole to Support Adolescent Pharmacokinetic Extrapolation and Label Extension in Chinese Patients With Gastroesophageal Reflux Disease (GERD).Semantic proximity Read ↗

Pharmacokinetics and Pharmacodynamics of Meloxicam in East Asian Populations: The Role of Ethnicity on Drug Response.Semantic proximity Read ↗

Population pharmacokinetics and exposure-response analysis of sotrovimab in the early treatment of COVID-19Semantic proximity Read ↗

Opicapone pharmacokinetics and pharmacodynamics comparison between healthy Japanese and matched white subjects.Semantic proximity Read ↗

Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.