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Article

Identification of butenolide regulatory system controlling secondary metabolism in Streptomyces albus J1074.

Scientific reports - 29 Aug 2017

Ahmed Yousra, Rebets Yuriy, Tokovenko Bogdan, Brötz Elke, Luzhetskyy Andriy

Abstract excerpt

A large majority of genome-encrypted chemical diversity in actinobacteria remains to be discovered, which is related to the low level of secondary metabolism genes expression. Here, we report the application of a reporter-guided screening strategy to activate cryptic polycyclic tetramate macrolactam gene clusters in Streptomyces albus J1074. The analysis of the S. albus transcriptome revealed an overall low level...

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Identifiers

PMID: 28852167
DOI: 10.1038/s41598-017-10316-y
PMCID: PMC5575351

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