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Article

Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development.

The EMBO journal - 12 Jun 2013

Hung Wesley L, Hwang Christine, Gao Shangbang, Liao Edward H, Chitturi Jyothsna, Wang Ying, Li Hang, Stigloher Christian, Bessereau Jean-Louis, Zhen Mei

Abstract excerpt

A neuronal F-box protein FSN-1 regulates Caenorhabditis elegans neuromuscular junction development by negatively regulating DLK-mediated MAPK signalling. In the present study, we show that attenuation of insulin/IGF signalling also contributes to FSN-1-dependent synaptic development and function. The aberrant synapse morphology and synaptic transmission in fsn-1 mutants are partially and specifically rescued by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23665919
DOI: 10.1038/emboj.2013.91
PMCID: PMC3680742

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INS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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