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IGFBP5 increases cell invasion and inhibits cell proliferation by EMT and Akt signaling pathway in Glioblastoma multiforme cells

27 Feb 2020

Abstract excerpt

BACKGROUND: Recurrence of Glioblastoma multiforme (GBM) seems to be the rule despite combination therapies. Cell invasion and cell proliferation are major reasons for recurrence of GBM. And insulin-like growth factor binding protein 5 (IGFBP5) is the most conserved of the IGFBPs and is frequently dysregulated in cancers and metastatic tissues. RESULTS: By studying the human glioma tissues, we find that IGFBP5...

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PMID: 32127912
DOI: 10.1186/s13008-020-00061-6

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