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Article

The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer.

BMC cancer - 3 Apr 2009

Akkiprik Mustafa, Hu Limei, Sahin Aysegul, Hao Xishan, Zhang Wei

Abstract excerpt

BACKGROUND: Insulin-like growth factor binding protein 5 (IGFBP5) has been shown to be associated with breast cancer metastasis in clinical marker studies. However, a major difficulty in understanding how IGFBP5 functions in this capacity is the paradoxical observation that ectopic overexpression of IGFBP5 in breast cancer cell lines results in suppressed cellular proliferation. In cancer tissues, IGFBP5 resides...

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Identifiers

PMID: 19341485
DOI: 10.1186/1471-2407-9-103
PMCID: PMC2670316

Genes

IGFBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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