Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.

doi:10.1016/j.ajpath.2013.03.023

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Article

Frequent genetic alterations in EGFR- and HER2-driven pathways in breast cancer brain metastases.

The American journal of pathology - 1 Jul 2013

Hohensee Ina, Lamszus Katrin, Riethdorf Sabine, Meyer-Staeckling Sönke, Glatzel Markus, Matschke Jakob, Witzel Isabell, Westphal Manfred, Brandt Burkhard, Müller Volkmar, Pantel Klaus, Wikman Harriet

Abstract excerpt

Current standard systemic therapies for treating breast cancer patients with brain metastases are inefficient. Targeted therapies against human epidermal growth factor receptors are of clinical interest because of their alteration in a subset of breast cancers (BCs). We analyzed copy number, mutation status, and protein expression of epidermal growth factor receptor (EGFR), human epidermal growth factor 2 (HER2),...

Topics

Biomarkers, Tumor
Bone Neoplasms
Brain Neoplasms
Breast Neoplasms
Carcinoma, Intraductal, Noninfiltrating
Class I Phosphatidylinositol 3-Kinases
DNA Copy Number Variations
DNA Mutational Analysis
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Expression Regulation, Neoplastic

Genes, erbB-1

Genes, erbB-2

Humans

Immunohistochemistry

In Situ Hybridization, Fluorescence

Kaplan-Meier Estimate

Mutation

PTEN Phosphohydrolase

Source

Open in PubMed

Identifiers

PMID: 23665199
DOI: 10.1016/j.ajpath.2013.03.023

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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