Article
Relevance of PTEN loss in brain metastasis formation in breast cancer patients.
Breast cancer research : BCR - 19 Mar 2012
Wikman Harriet, Lamszus Katrin, Detels Niclas, Uslar Liubov, Wrage Michaela, Benner Christian, Hohensee Ina, Ylstra Bauke, Eylmann Kathrin, Zapatka Marc, Sauter Guido, Kemming Dirk, Glatzel Markus, Müller Volkmar, Westphal Manfred, Pantel Klaus
Abstract excerpt
INTRODUCTION: With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer. METHODS: Patterns of chromosomal aberrations in primary breast tumors and brain metastases were...
Topics
- Allelic Imbalance
- Brain Neoplasms
- Breast Neoplasms
- Chromosome Aberrations
- Chromosome Deletion
- Chromosomes, Human, Pair 10
- Comparative Genomic Hybridization
- ErbB Receptors
- Female