Article

Identification of targetable genomic profiling of breast cancer brain metastases identifies alterations and genomic signatures relevant to immune-checkpoint and PARP inhibitors

2023-01-27

Abstract excerpt

<title>Abstract</title><p>Understanding the genomic landscape of breast cancer brain metastases (BCBMs) is key to elucidating their cause and developing novel treatments. In this study, comprehensive genomic profiling was performed on 822 BCBMs, 11,988 local breast cancer (BC) biopsies and 15,516 non-central nervous system (N-CNS) metastases (all unpaired samples). Clinically-relevant genomic alterations were sign...

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Literature Corpus work: 9d1ef128-28a4-5253-8a34-7d58c0056d61
DOI: 10.21203/rs.3.rs-2484456/v1

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