Article
Impact of inherited genetic variants associated with lipid profile, hypertension, and coronary artery disease on the risk of intracranial and abdominal aortic aneurysms.
Circulation. Cardiovascular genetics - 1 Jun 2013
van 't Hof Femke N G, Ruigrok Ynte M, Baas Annette F, Kiemeney Lambertus A L M, Vermeulen Sita H, Uitterlinden André G, Hofman Albert, Rivadeneira Fernando, Rinkel Gabriël J E, de Bakker Paul I W
Abstract excerpt
BACKGROUND: Epidemiological studies show that an unfavorable lipid profile and coronary artery disease (CAD) are risk traits for abdominal aortic aneurysms (AAAs) but not for intracranial aneurysms (IAs), and that hypertension is a main risk trait for IAs but not for AAAs. To evaluate these observations, we investigated single-nucleotide polymorphisms associated with serum lipid levels, hypertension, and CAD and...
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