Article
A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm.
Human molecular genetics - 15 Jul 2013
Jones Gregory T, Bown Matthew J, Gretarsdottir Solveig, Romaine Simon P R, Helgadottir Anna, Yu Grace, Tromp Gerard, Norman Paul E, Jin Cao, Baas Annette F, Blankensteijn Jan D, Kullo Iftikhar J, Phillips L Victoria, Williams Michael J A, Topless Ruth, Merriman Tony R, Vasudevan Thodor M, Lewis David R, Blair Ross D, Hill Andrew A, Sayers Robert D, Powell Janet T, Deloukas Panagiotis, Thorleifsson Gudmar, Matthiasson Stefan E, Thorsteinsdottir Unnur, Golledge Jonathan, Ariëns Robert A, Johnson Anne, Sohrabi Soroush, Scott D Julian, Carey David J, Erdman Robert, Elmore James R, Kuivaniemi Helena, Samani Nilesh J, Stefansson Kari, van Rij Andre M
Abstract excerpt
Abdominal aortic aneurysm (AAA) is a common human disease with a high estimated heritability (0.7); however, only a small number of associated genetic loci have been reported to date. In contrast, over 100 loci have now been reproducibly associated with either blood lipid profile and/or coronary artery disease (CAD) (both risk factors for AAA) in large-scale meta-analyses. This study employed a staged design to...
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